Cat No:LP000313
Product Name:U-104;NSC 213841
CAS#178606-66-1
Molecular Formula:C13H12FN3O3S
Molecular Weight:309.32
Carbonic anhydrases are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide to form bicarbonate ion plus a proton. Carbonic anhydrases IX (CAIX) and CAXII are hypoxia and HIF-1-inducible proteins located in cellular transmembranes that regulate intra- and extracellular pH under hypoxic conditions and promote tumor cell survival and invasion in hypoxic microenvironments. U-104 is a ureido-sulfonamide inhibitor of transmembrane CAIX (Ki = 45.1 nM) and CAXII (Ki = 4.5 nM).1 It demonstrates reduced affinity for the cytosolic isoforms, CAI and CAII (Kis = 5.08 and 9.64 µM, respectively).1 U-104 associates with CAIX/CAXII only under hypoxic conditions in vivo, reducing extracellular acidity and resulting in significant inhibition of tumor growth and metastasis in experimental models.
