Cat No:LP000096
Product Name:Foretinib;GSK1363089;XL880
CAS NO:849217-64-7
Purity: ≥99%
Solubility: In DMSO
Storage: -10°C
Foretinib is a broad-spectrum tyrosine kinase (TK) inhibitor that targets members of the HGF and VEGF receptor TK families, as well as KIT, Flt-3, PDGFRβ, and Tie-2, at nanomolar concentrations.1,2 It blocks HGF-induced Met phosphorylation and VEGF-induced ERK phosphorylation, preventing HGF-induced responses in tumor cells and HGV/VEGF-induced responses in endothelial cells.1,3 Foretinib is functional in vivo, reducing tumor burden in an experimental model of lung metastasis.
