Cat No:LP000213
Product Name:XL647
CAS No:781613-23-8
Purity: ≥99%
Solubility: In DMSO
Storage: -10°C
XL-647 potently inhibits the EGF/ErbB2, VEGF, and ephrin RTK families. XL-647 is a reversible and ATP competitive inhibitor. XL-647 was inactive against a panel of 10 tyrosine kinases (including the insulin and the insulin-like growth factor-1 receptor) and 55 serine-threonine kinases (including cyclin-dependent kinases, stress-activated protein kinases, and protein kinase C isoforms). XL-647 inhibits cellular proliferation and EGFR pathway activation in the erlotinib-resistant H1975 cell line that harbors a double mutation (L858R and T790M) in the EGFR gene. In A431 cells, XL-647 reduces cell viability with IC50 values of 13 nM[1].
XL-647 shows potent and long-lived inhibition of the WT EGFR in vivo. XL-647 substantially inhibits the growth of H1975 xenograft tumors and reduces both tumor EGFR signaling and tumor vessel density[1].
