Name: AG-1024
CAS#: 65678-07-1
Chemical Formula: C14H13BrN2O
Exact Mass: 304.02113
Molecular Weight: 305.16982
Elemental Analysis: C, 55.10; H, 4.29; Br, 26.18; N, 9.18; O, 5.24
Description: AG-1024 is also called Tyrphostin, is a selective inhibitor of IGF-1R. AG-1024 was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. Exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Tyrphostin AG 1024 could be used as a potential therapeutic agent in combination with irradiation.
