Cat No:LP0000246
Product Name:RI-1,RAD51,inhibitor
CAS No:415713-60-9
Purity: ≥99%
Solubility: In DMSO
Storage: -10°C
RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM. IC50 Value: 5-30 μM Target: RAD51 in vitro: RI-1 sensitizes cells to DNA damage by directly and specifically disrupting HsRAD51 and inhibiting the ability of RAD51 to form filaments on ssDNA. In addition, RI-1 alone generates single-agent toxicity in all three cancer cell lines (HeLa, MCF-7 and U2OS) with LD50 values in the 20–40 μM range. RI-1 decreases the rejoining of γ-H2AX foci in G2 phase cells and results in a higher level of unrepaired DSBs 6 hours after irradiation.
