Cat No:LP000293
Product Name:SB 525334
CAS No:356559-20-1
Purity:≥99%
Solubility: In DMSO
Storage:at -20°C 2 years
SB-525334 is a potent inhibitor of the TGF-β receptor 1 (TGF-β R1, ALK5) kinase (IC50 = 14.36 nM).1 It is ~4-fold less effective against ALK4 and inactive against ALK2, ALK3, and ALK6.1 SB-525334 blocks TGF-β1-induced phosphorylation and nuclear translocation of SMAD2/3 as well as TGF-β1-directed gene expression.1 It is effective in vivo, preventing puromycin aminonucleoside-induced renal fibrosis and bleomycin-induced pulmonary fibrosis.1,2,3 SB-525334 also modulates carcinogenesis and suppresses the development of pulmonary arterial hypertension in animals.
