Cat No:LP000220
Product Name:PR-619;2,6-Diamino-3,5-dithiocyanopyridine
CAS No:2645-32-1
Purity: ≥99%
Solubility: In DMSO
Storage: -10°C
PR-619, a deubiquitylase inhibitor, prevents degradation, indicating KCa3.1 is targeted for degradation by ubiquitylation. In PR-619 treated cells, channel degradation is significantly inhibited with 87±1% of KCa3.1 still remaining after 24 hrs (n=3; P<0.05)[2]. Cell viability is determined by MTT assay and revealed that PR-619 exerted concentration-dependent cytotoxicity in a very narrow concentration range of 7-10 μM[3].
