Catalog No:LP000107
Product Name:Pelitinib,EKB-569
CAS NO:257933-82-7
Purity: ≥99%
Solubility: In DMSO
Storage: -10°C
Pelitinib is a cyanoquinoline that irreversibly inhibits the EGFR receptor tyrosine kinase (IC50 = 39 nM).1 It inhibits HER2 with a much weaker potency (IC50 = 1.2 μM).1 By disrupting Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth of tumor cell lines, displaying particularly strong efficacy against hepatocellular carcinoma cells (IC50s = ~2 μM).2
