Cat No:LP000324
Product Name:TA-02
CAS#1784751-19-4
Molecular Formula:C20H13F2N3
Molecular Weight:333.33
TA-02 is a derivative of the p38 MAPK inhibitor SB 203580 (Item Nos. 13067 | 13344) and an inducer of cardiomyocyte differentiation.1 It is cardiomyogenic, increasing expression of the cardiomyocyte marker NKX2-5 by greater than 2-fold and decreasing expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5eGFP/w cells when applied after embryoid body formation at a concentration of 5 μM. TA-02 inhibits casein kinase 1ε (CK1ε) and CK1D and reduces expression of Wnt/β-catenin signaling pathway members, activities that positively correlate with its cardiomyogenic activity.
