Cat No:LP000105
Product Name:Roflumilast;B 9302-107;BY 217;BY 217;Daxas
CAS NO:162401-32-3
Purity: ≥99%
Solubility: In DMSO
Storage: -10°C
Type 4 cyclic nucleotide phosphodiesterase (PDE4) isoforms selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP.1 Roflumilast is a potent, cell-permeable inhibitor of PDE4 (IC50 = < 1 nM for both human PDE4B and PDE4D).2 It is selective for PDE4, with IC50 values against other PDE forms being greater than 10 μM.2 Roflumilast demonstrates good bioavailability and has applications in respiratory diseases, including asthma and chronic obstructive pulmonary disease.
