Cat No:LP000383
Product Name:ARN-3236
CAS#1613710-01-2
ARN-3236 is a novel potent, selective, and orally active SIK2 inhibitor with IC50 of <1 nM; does not significantly inhibit SIK1 and SIK3, as well as other AMPK family members; inhibits the growth of 10 ovarian cancer cell lines with IC50 of 0.8-2.6 uM; increasess centrosome uncoupling from nucleus, and inhibits centrosome splitting in mitotic cells; induces cell cycle arrest, apoptosis and tetraploidy, also inhibits AKT phosphorylation and attenuates survivin expression; sensitizes ovarian cancer to paclitaxel in SKOv3ip xenograft model.
