Cat No:LP000321
Product Name:BMS-5;LIMKi 3;LIM Kinase Inhibitor I
CAS#1338247-35-0
Molecular Formula:C17H14Cl2F2N4OS
Molecular Weight:431.29
BMS-5 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 with IC50 values of 7 and 8 nM, respectively.1 LIMK1 and LIMK2 participate in signal pathways affecting actin dynamics by deactivating cofilin.2,3 This compound can be used to study the role of activated LIMK isoforms in the signaling of Rho family GTPases to cytoskeletal proteins, including cofilin.
