Cat No:LP000364
Product Name:AS703026;Pimasertib; MSC1936369B
CAS#1236699-92-5
AS703026 (5, 0.5, and 0.1 μM) specifically blocks ERK1/2 activation in MM cells, cultured alone or with BMSCs. AS703026 inhibits the growth of MM cell lines in a dose-dependent manner, with IC50s ranging from 0.005 to 2 μM. The IC50s of AS703026 against INA-6, U266, H929 cells are 10 nM, 5 nM, 200 nM respectively. AS703026 induces apoptosis and modulates the cell cycle profile. AS703026 targets MM cells in the BM microenvironment[1]. AS703026 (10 μmol/L) inhibits ERK pathway, proliferation, and transformation in cetuximab-resistant D-MUT cells[2]. AS703026 in combination with PLX4032 significantly induces apoptosis of RPMI-7951 cells, whereas each drug used alone does not. AS703026 synergizes with small interfering RNA-mediated downregulation of BRAF to produce results similar to those of combined treatment with PLX4032 and AS703026.
