Cat No:LP000332
Product Name:WZB117
CAS#1223397-11-2
Molecular Formula:C20H13FO6
Molecular Weight:368.31
WZB117 is an irreversible inhibitor of glucose transporter 1 (Glut1) that blocks glucose transport in diverse cancer cells (IC50 = ~0.6 µM), reducing extracellular lactate and intracellular ATP levels.1 It inhibits cancer cell proliferation (IC50s = 5-10 µM), resulting in cell cycle arrest, senescence, and necrosis or apoptosis.1,2 These effects are enhanced by the anticancer drugs cisplatin (Item No. 13119) and paclitaxel (Item No. 10461). WZB117, given intraperitoneally at 10 mg/kg, significantly reduces tumor size in mice, with only small reductions in body weight and leukocyte count.1 WZB117 also inhibits the self-renewal and tumor-initiating capacity of cancer stem cells, blocking tumor initiation after implantation of cancer stem cells in mice.
