Cat No:LP000073
Product Name:PF-05212384;PKI-587;PK-1587
CAS NO:1197160-78-3
Purity: ≥99%
Solubility: In DMSO
Storage: -10°C
Phosphatidylinositol-3-kinases (PI3Ks) act in concert with mTOR complexes to regulate signaling pathways that have critical roles in cancer and other diseases.1,2 PF-05212384 is a potent, dual PI3K/mTOR inhibitor (IC50 values are 0.4 and 5.4 nM for PI3Kα and PI3Kγ, respectively, and 1.6 nM for mTOR).3,4 It is active both in vitro and in vivo, inhibiting the growth of cancer cells in culture or in xenografts in mice when delivered intravenously.3,4 PF-05212384 blocks the proliferation of liver cancer stem cells, and this effect is enhanced in combination therapy with the multikinase inhibitor BAY-43-9006 (Item No. 10009644).5 PF-05212384 action also enhances the effectiveness of cetuximab or radiation therapy in human head and neck cancer models.
