Cat No:LP000132
Product Name:CP466722
CAS No:1080622-86-1
Purity: ≥99%
Solubility: In DMSO
Storage: -10°C
CP-466722 (CP466722, 6-10 μM) inhibits IR-induced ATM kinase activity, and the inhibition can be rapidly and completely reversed. CP466722 (6, 10 μM) inhibits p53 induction and ATM-dependent phosphorylation in mouse cells, but CP466722 fails to inhibit ATR activity and ATR-dependent phosphorylation of Chk1. CP466722 (6 μM) disrupts ATM-dependent cell cycle checkpoints in cells[1]. CP466722 (1 µM) completely inhibits ATM-dependent phosphorylation in MCF7 cells. CP466722 (10 µM) reduces pKAP1 phosphorylation in MCF7 cells, with an IC50 of 0.41 µM. CP466722 (10 µM) inhibits both pATM and pKAP1 signals[2]. CP-466722 (CP466722, 5-50 μM) inhibits proliferation of SKBr-3 cancer cells more strongly than MCF-7 cancer cells. CP466722 (10 µM) also slightly increases proportions of MCF-7 and SKBr-3 cells in the G1 phase after treatment for 48 hours[3]
