Cat No:LP000099
Product Name:PLX4032;RG-7204;Ro 51-85426;Vemurafenib
CAS NO:1029872-54-5
Purity: ≥99%
Solubility: In DMSO
Storage: -10°C
PLX4032 is an orally bioavailable, ATP-competitive inhibitor of mutant V600E and wild type B-Raf kinases (IC50s = 31 and 100 nM, respectively).1 It inhibits cell proliferation in a variety of cell lines expressing B-Raf V600E and synergizes strongly with taxol, vinblastine, and oxaliplatin in inhibiting the proliferation of B-RafV600E transformed cancer cells.1 PLX4032 is effective against the growth of tumors bearing the B-Raf V600E mutation.
