PCI-32765

Cat No:LP000112 Product Name:PCI-32765;Ibrutinib CAS NO:936563-96-1 Purity: ≥99% Solubility: In DMSO Storage: -10°C PCI-32765 selectively inhibits B-cell signaling and activation. It inhibits autophosphorylation of Btk (IC50=11 nM), phosphorylation of Btk’s physiological substrate PLCγ (IC50=29 nM), and phosphorylation of a further downstream kinase, ERK (IC50=13 nM)[1]. PCI-32765 inhibits BCR-activated primary B cell proliferation (IC50=8 nM). Following…