P7C3-A20

Cat No:LP000004 Product Name:P7C3-A20; CAS:1235481-90-9 Purity:99%+ In Stock P7C3-A20 is an analogue of P7C3, and is a proneurogenic, neuroprotective agent. P7C3-A20 exerted an antidepressant-like effect in wild-type littermates than P7C3. display increased activity and an improved toxicity profile compared to P7C3. P7C3 is a NAMPT activator. In vivo: The P7C3-A20 exhibited antidepressant efficacy both in…

GDC-0068

Cat No:LP000003 Product Name:GDC-0068; CAS:1001264-89-6 Purity:99%+ In Stock GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays.1 It is 620-fold selective for Akt over protein kinase A and has been shown to block Akt signaling selectively in cultured…

SB216763

Cat No:LP000002 Product Name: SB 216763 ; Chem Name:3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione; CAS: 280744-09-4 Purity:99%+ In Stock SB-216763 (10-20 µM) induces β-catenin mediated-transcription in a dose-dependent manner in HEK293 cells. SB-216763 (10, 15 and 20 µM) can maintain mESCs with a pluripotent-like morphology in long-term culture. SB-216763 (10 µM) can maintain J1 mESCs in a pluripotent state for…

OTSSP167

Cat No:LP000001 Product Name:OTSSP167 CAS:1431697-89-0 Formula:C25H28Cl2N4O2 Purity:99%+ Maternal embryonic leucine zipper kinase (MELK) is a serine/threonine kinase that regulates signaling central to cell cycling, stem cell renewal, apoptosis, and other cellular processes.1 MELK is overexpressed in some forms of cancer, particularly those with aggressive undifferentiated tumors.2,3,4 OTSSP167 is a potent inhibitor of MELK (IC50 =…