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Name: AT7867
CAS#: 857531-00-1 (free base)
Chemical Formula: C20H20ClN3
Exact Mass: 337.13458
Molecular Weight: 337.8459
Elemental Analysis: C, 71.10; H, 5.97; Cl, 10.49; N, 12.44
AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A. This ATP-competitive small molecule potently inhibits both AKT and p70S6K activity at the cellular level, as measured by inhibition of GSK3beta and S6 ribosomal protein phosphorylation, and also causes growth inhibition in a range of human cancer cell lines as a single agent.

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