Name: AR-A014418
CAS#: 487021-52-3
Chemical Formula: C12H12N4O4S
Exact Mass: 308.05793
Molecular Weight: 308.31
Elemental Analysis: C, 46.75; H, 3.92; N, 18.17; O, 20.76; S, 10.40
Description: AR-A014418 , also known as SN 4521, is a labeled Glycogen Synthase Kinase 3β (GSK-3β) inhibitor. AR-A014418 suppresses pancreatic cancer cell growth via inhibition of GSK-3-mediated Notch1 expression. AR-A014418 decreases neuropathic pain in mice: evidence for the mechanisms of action. AR-A014418 and B6B3O prevent human immunodeficiency virus-mediated neurotoxicity in primary human neurons.
