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Name: Fimepinostat
CAS#: 1339928-25-4
Chemical Formula: C23H24N8O4S
Exact Mass: 508.16412
Molecular Weight: 508.55
Elemental Analysis: C, 54.32; H, 4.76; N, 22.03; O, 12.58; S, 6.31
Description: CUDC-907, also known as fimepinostat, is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, CUDC-907 inhibits the activity of both PI3K class I isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction pathway that is often overactivated in many cancer cell types. This may prevent growth of PI3K and/or HDAC-expressing tumor cells. CUDC-907 shows an increased inhibition of tumor cell growth and induction of apoptosis when compared to inhibitors that target either PI3K or HDAC.

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